Objectives. Acute lung injury (ALI) is a common clinical critical disease. Stem cells transplantation is recognized as an effective\nway to repair injured lung tissues. The present study was designed to evaluate the effects of mesenchymal stem cells (MSCs) on\nrepair of lung and its mechanism. Methods. MSCs carrying GFP were administrated via trachea into wild-type SD rats 4 hours\nlater after LPS administration.The lung histological pathology and the distribution of MSCs were determined by HE staining and\nfluorescence microscopy, respectively. Next, differentially expressed HOX genes were screened by using real-time PCR array and\nabnormal expression and function of Hox A9 were analyzed in the lung and the cells. Results. MSCs promoted survival rate of ALI\nanimals. The expression levels ofmultipleHOX genes had obvious changes after MSCs administration and HOX A9 gene increased\nby 5.94-fold after MSCs administration into ALI animals. HOX A9 was distributed in endothelial cells and epithelial cells in animal\nmodels and overexpression of Hox A9 can promote proliferation and inhibit inflammatory adhesion of MSCs. Conclusion. HoxA9\noverexpression induced by MSCs may be closely linked with lung repair after endotoxin shock.
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